Objective To explore the role of serum free immunoglobulin light chain (FLC) in the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung inflammation in smokers with normal lung function.Methods From January 2014 to December 2015, it selected 60 cases of smoking patients with COPD as the group A, 60 cases of smokers with normal pulmonary function as the group B and 60 cases of non-smokers with normal pulmonary function as the group C.Their serum FLC-κ, FLC-λ and other indicators were compared.Results The serum levels of FLC-κ and FLC-λ were higher in the group A than in the group B and C (P<0.05), and they were higher in the group B than in the group C (P<0.05).The serum IL-8, TNF-α and N were higher in the group A than in the group B and C, and serum FEV1, FVC levels were lower in the group A than in the group B and C (P<0.05).The serum IL-8, TNF-α and N were higher in the group B than in the group C.Serum FEV1 and FVC levels were lower in the group B than in the group C (P<0.05).The difference of serum FLC-κ and FLC-λ in smokers with normal lung function and smoking COPD patients showed a significant positive correlation with IL-8 and TNF-α (P<0.05).Conclusion The serum level of FLC has a role in promoting inflammation in COPD and smokers with normal lung function.%目的 探讨血清游离免疫球蛋白轻链(Free immunoglobulin light chain,FLC)在慢性阻塞性肺疾病(Chronic obstructive pulmonary disease)和吸烟肺功能正常者肺部炎症机制中的作用.方法 选取2014年1月-2015年12月本院收治的60例吸烟伴慢阻肺患者(A组)、吸烟肺功能正常对象60例(B组)、不吸烟肺功能正常对象60例(C组),检测两组血清FLC-κ、FLC-λ等指标并进行比较分析.结果 A组患者的血清FLC-κ、FLC-λ水平高于B组、C组患者,差异具有统计学意义(P<0.05),B组患者的血清FLC-κ、FLC-λ水平高于C组患者,差异具有统计学意义(P<0.05);A组患者的血清白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、中性粒细胞(Neutrophil, N)水平高于B组、C组患者, 第一秒用力呼气容积(Forced expiratory volume in one second,FEV1)、用力肺活量(Forced vital capacity,FVC)水平低于B组、C组患者差异具有统计学意义(P<0.05);B组患者的血清血清IL-8、TNF-α、N水平高于C组患者, FEV1、FVC水平低于C组患者差异具有统计学意义(P<0.05);吸烟伴慢阻肺患者、吸烟肺功能正常对象血清FLC-κ、FLC-λ水平与IL-8、TNF-α呈显著的正相关关系(P<0.05).结论 血清游FLC在COPD和吸烟肺功能正常者肺部炎症反应中具有促炎症作用.
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