肺癌化疗患者CEA、NSE、SCC-Ag与血小板相关性分析

摘要

目的 分析肺癌化疗患者血清肿瘤标志物与血小板参数间的相关性,以期优化肺癌患者临床诊断、治疗观察方案,提升肺癌患者诊治水平.方法 选择2015年1月-2015年12月我院收治行化疗的肺癌患者68例作为研究对象设为观察组,选取同期行健康体检的68例受试者作为对照组,采集对照组患者静脉血、观察组化疗前、完成化疗周期后静脉血,采用电化学方法检测上述血清中的癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、鳞状上皮细胞癌抗原(SCC-Ag)的水平并比较,同样标本检测血小板参数(血小板计数、平均体积、血小板宽度、血小板压积)并比较.将观察组患者治疗前、后的血清肿瘤标志物和血小板参数结果 纳入相关性分析体系中,采用pearson相关程序分析血清肿瘤标志物与血小板计数间的相关性.结果观察组患者血清CEA、NSE、SCC-Ag、血小板参数(血小板计数、平均体积、血小板宽度、血小板压积)治疗前明显高于治疗后(P<0.05),治疗前后均明显高于对照组患者(P<0.05).pearson相关系数分析显示,血清CEA、NSE、SCC-Ag分别与血小板计数、血小板体积、血小板压积呈正相关,与血小板宽度相关性弱.结论 肺癌患者血清肿瘤标志物与血小板参数间呈现较高的相关性,可作为肺癌诊断和治疗观察的有益参考,具有进一步研究肿瘤标志物与血小板参数合理组合指导临床诊治的价值.%Objective To analyze the correlation between serum tumor markers and platelet parameters in pa-tients with lung cancer under chemotherapy, so as to optimize the clinical diagnosis and treatment of patients with lung cancer and improve the level of diagnosis and treatment. Methods From January to December, 2015, 68 lung cancer patients were selected as the observation group, and another 68 healthy subjects were taken as the control group. Their venous blood of the control group was collected, and their venous blood before and after chemotherapy in the observation group was collected. It used electrochemical method to detect the serum levels of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and squamous cell carcinoma antigen (SCC-Ag). The platelet parameters (platelet count, mean platelet volume, width, plateletcrit and comparison) were detected and compared. It used Pearson pro-gram to analyze the correlation between serum tumor markers and platelet count. Results The levels of serum CEA, NSE, SCC-Ag, platelet count, mean platelet volume, width, and platelet hematocrit was significantly higher before treatment than after in the observation group ( P<0. 05 ) , and they were also significantly higher in the observation group than in the control group (P<0. 05). Pearson correlation coefficient analysis showed that serum CEA, NSE and SCC-Ag were positively correlated with platelet count, platelet volume and platelet volume, but the correlation with platelet width was weak. Conclusion The serum tumor markers in patients with lung cancer show a high correlation with the platelet parameters, which can be used as a useful reference for lung cancer diagnosis and treatment observa-tion. It has certain guidance for clinical diagnosis and treatment to further study the reasonable combination of tumor markers and platelet parameters.