阿立哌唑联合米氮平对难治性精神分裂症患者认知功能的影响

摘要

目的 探讨阿立哌唑联合米氮平治疗难治性精神分裂症的疗效以及对患者认知功能的影响,旨在为临床治疗提供依据.方法 将100例难治性精神分裂症患者按照治疗方式分为两组,每组50例.对照组予以阿立哌唑治疗,观察组予以阿立哌唑联合米氮平治疗,观察6周.治疗前后采用阳性与阴性症状量表、威斯康星分类测验评定临床疗效及认知功能. 结果 治疗6周末,观察组总有效率为92%,对照组为76%,观察组显著高于对照组(P<0.05).治疗后两组威斯康星分类测验各项指标检测结果均较治疗前显著改善,观察组显著优于对照组(P<0.01).观察组不良反应发生率为16%,对照组为20%,两组比较差异无统计学意义(P>0.05).结论 阿立哌唑联合米氮平治疗难治性精神分裂症临床疗效显著,且能显著改善患者的认知功能,优于单用阿立哌唑治疗.%Objective To explore the effects of aripiprazole combined with mirtazapine on cognitive function of refractory schizophrenics (RS) in order to provide basis for clinical treatment.Methods A total of 100 RS patients were assigned to two groups of 50 ones each according to treatment methods.Control group was treated with aripiprazole and observation with aripiprazole plus mirtazapine for 6 weeks.Before and after treatment efficacies and cognitive functions were assessed with the Positive and Negative Syndrome Scale (PANSS) and Wisconsin Card Sorting Test (WCST) respectively.Results At the end of the 6th week total effective rate was respectively 92% in observation and 76% in control group and the former significantly higher than the latter (P<0.05).After treatment all indexes detection results of the WCST of both groups improved more significantly compared with pretreatment and were significantly better in observation than in control group (P<0.01).The incidence of adverse reactions was respectively 16% in observation and 20% in control group and had no notable group difference (P>0.05).Conclusion Aripiprazole combined with mirtazapine have an evident effect in the treatment of refractory schizophrenia and could notably improve patients' cognitive function compared with single aripiprazole.