2～3岁广泛性发育障碍儿童脑体积的对照研究

摘要

Voxel based morphometry( VBM) in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 50 children with PDD and 36 children with developmental delay. Results:Compared with children with developmental delay,the volume of total brain,total gray matter and total white matter of children with PDD was significantly larger (P < 0.05). Significant enlargement was present in meditemporal gyms and superior temporal gyrus in grey matter while diminution in right precentral gyrus and left parietal gyrus. Significant enlargement also detected in medifrontal gyrus, left superior frontal gyrus, left midtemporal gyrus, right midfrontal gyrus, right transverse temporal gyrus ( P < 0. 001 ). Conclusion: The findings indicate structural grey and white matter in several brain regions is significantly abnormal in children with PDD.%目的:对比分析2～3岁广泛性发育障碍儿童的脑体积异常. 方法:对50例广泛性发育障碍儿童(病例组)和36名年龄、性别、智商与之相匹配的发育障碍儿童(对照组)进行T1加权三维磁共振成像扫描,应用基于体素的形态测量法比较两组全脑和脑灰、白质体积的差异. 结果:与对照组相比,2～3岁广泛性发育障碍儿童全脑及脑灰、白质体积显著增大(P＜0.05)；左侧颞中回及颞上回灰质体积显著增大；右侧中央前回、左侧中央后回灰质体积显著减小；额中回、左侧额上回、左侧颞中回、右侧额中回及右侧颞横回处脑白质体积显著增大(P＜0.001). 结论:2～3岁广泛性发育障碍儿童可能存在多个脑区体积异常改变..