目的:探讨焦虑症患者心率变异性异常的一些相关影响因素. 方法:选取焦虑症患者(焦虑症组)80例和健康志愿者(正常对照组)80名完成一般情况问卷及病史问卷、汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)评定,同时采用24小时动态心电图记录器测定两组被试心率变异性(HRV)指标,并进行比较. 结果:焦虑症组平均心率显著高于正常对照组(t=6.79,P＜0.01).焦虑症组HRV所有指标均低于对照组(P＜0.05或P＜0.01),其中SDNN、RMSSD、PNN50、HF及LF/HF与对照组相比差异有统计学意义(t分别=-11.95,-5.34,-4.79,-2.69,-2.93；P均＜0.01).不同性别(F =5.500)、不同年龄段(F=270.39)两组被试平均心率指标差异有统计学意义(P＜0.05或P＜0.01). 结论:焦虑症患者自主神经功能紊乱与性别、年龄有关.%Objective: To explore the factors which can have influence on autonomic nervous function in patients with anxiety. Method: 80 anxiety patients and 80 healthy volunteers were assessed using general information sheet, Hamilton anxiety scale(HAMA)and Hamilton depression scale (HAMD) , and 24 hour ambulatory electrocardiography record was conducted to measure indexes of HRV. Results: Anxiety group showed higher average heart rate (t = 6. 79, P < 0.01) and lower other HRV indexes (P < 0. 05 or P < 0. 01); there were statistically significant differences in SDNN, RMSSD, PNN50, HF and LF/HF (t = - 11. 95, -5. 34, - 4. 79 , - 2. 69 , - 2. 93 ; all P < 0. 01 ) . The sex and age difference in average heart rate were found (F = 5. 500, P<0.05; F = 270. 39, P <0. 01). Conclusion: Autonomic nervous dysfunction in anxiety patients is relevant with sex and age.
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