两种无抽搐电休克治疗模式对抑郁症患者疗效及记忆力影响的比较

摘要

Objective:To explore the influence of the standard stimulus of Thymatron (DGX) and the Fixed 0.5ms pulse-width mode (LOW 0.5) MECT on efficacy and cognitive function in patients with depression.Method:65 patients with depression were randomly divided into the DGX group and the LOW 0.5 group and received 6 to 12 times therapies of MECT.Hamilton depression scale (HAMD-17) was used to assess the severity of depression and the Wechsler memory scale (WMS) was employed to assess the memory function before and after MECT,respectively.Results:The HAMD scores in both groups significantly decreased after MECT (t =14.67,12.41,both P ＜ 0.05),despite ANCOVA showed no significant between-group difference in the D-value of HAMD (F =0.698,P ＞ 0.05).The WMS scores in two groups were comparable at the baseline.ANCOVA revealed that the pictures,recognition,digit span and total scores of the LOW 0.5 group were significantly higher than those of the DGX group (F=9.127,7.312,13.261,5.135,all P ＜0.05).Conclusion:The DGX mode and LOW 0.5 mode MECT has similar efficacy on treating depressive disorder;however,the LOW 0.5 mode may have better effect on improving memory function.%目的:比较两种无抽搐电休克治疗(MECT)模式对抑郁症患者疗效及记忆力的影响.方法:将65例抑郁症患者随机分为醒脉通标准电刺激组(DGX组)和0.5 ms波宽模式组(LOW 0.5组),分别给予6 ～12次MECT治疗.治疗前后用汉密尔顿抑郁量表(HAMD-17)评定疗效,用韦氏记忆量表(WMS)进行记忆测定. 结果:DGX组和LOW 0.5组末次MECT治疗后的HAMD评分均较治疗前显著下降(t=14.67、12.41,P均＜0.05);协方差分析显示治疗前后HAMD评分差值组间差异无统计学意义(F =0.698,P＞0.05);治疗前两组WMS评分差异无统计学意义(P均＞0.05),协方差分析显示治疗后LOW 0.5组在图片、再认、背数等项目以及记忆商数上的得分显著高于DGX组(F=9.127、7.312、13.261、5.135;P均＜0.05). 结论:LOW 0.5模式与DGX模式MECT的抗抑郁效果相当;但在改善记忆力方面LOW 0.5模式优于DGX模式.