首次躁狂发作未服药患者血清尿酸水平的研究

摘要

Objective:To investigate the serum uric acid(UA)level and its relative factors in first-epi-sode and unmedicated patients with manic episode. Method:The serum UA level was detected in 105 first-episode and unmedicated patients with manic(case group)and 105 healthy controls(control group). The se-verity of manic symptom of the case group was assessed by Young mania rating scale(YMRS). Results:The serum UA level in the case group[(371.17 ± 103.63)μmol/L]was significantly higher than the control group [(301.10 ± 78.40)μmol/L](P<0.01).The rate of hyperuricemia(HUA)in the case group(35.2%,37 cases)was significantly higher than the control group(8.5%,9cases)(P<0.01).There were statistically sig-nificant differences in serum UA level between male patients[(371.17 ± 103.63)μmol/ L]and male controls [(301.10 ± 78.40)μmol/L],and between female patients[(333.80 ± 100.71)μmol/ L]and female controls [(263.06 ± 64.23)μmol/L](all P<0.05).Correlation analysis showed that serum UA level had no signifi-cant correlation with scores of YMRS(P>0.05). Conclusion:The serum UA level in first-episode and drug-native patients with manic is higher;but it is not correlated with the degree of mania.%目的:探讨首次躁狂发作未用药患者血清尿酸(UA)水平及其临床影响因素. 方法:检测105例首次躁狂发作未用药患者(患者组)和105名健康对照者(对照组)血清UA水平,同时采用杨氏躁狂量表(YMRS)评估躁狂症状严重程度. 结果:患者组血清UA水平[(371.17 ± 103.63)μmol/L]显著高于对照组[(301.10 ± 78.40)μmol/L](P<0.01);高尿酸血症(HUA)发生率(35.2%,37例)显著高于对照组(8.5%,9例)(P<0.01);患者组男性[(399.20 ± 99.35)μmol/L]和对照组男性[(329.62 ± 76.34)μmol/L]之间、患者组女性[(333.80 ± 100.71)μmol/L]与对照组女性[(263.06 ± 64.23)μmol/L]之间血清UA水平差异有统计学意义(均P<0.01).相关分析显示血清UA水平与YMRS评分无相关(P>0.05). 结论:首次躁狂发作未用药患者血清UA水平升高,但其与躁狂病情无关.