肺通气功能指标FEF75在儿童哮喘降级治疗中的作用

摘要

Objective To evaluate ihe role of lung function parameter FEF75 (75% forced expiratory flow) in step-down therapy in asthmatic children. Methods A total of 108 children with severe or moderate asthma received regimens including ICS plus EABA. When the asthma was in control, the lung function was tested before these children underwent step-down therapy. They were divided into two groups according to FFF75. The control conditions were compared before and after treatment. Results After step-down therapy, children with normal FEF75, compared to abnormal FEF75 group, had higher control rales, lower partially controlled and uncontrolled rates (X2 = 12.89, P < 0.05). When LABA were withdraw, the uncontrolled rate increased significantly in patients with abnormal FEF7S ( x2 = 8.65, P < 0.05). Conclusions FEf75 could be a good index of successful step-down therapy in severe or moderate asthmatic children.%目的 评价肺通气功能指标FEF75(用力呼气75％肺活量时气道流速)在儿童哮喘降级治疗中的作用. 方法 将符合中、重度哮喘诊断标准的8～14岁儿童共108例,经联合吸入治疗(吸入糖皮质激素+长效β2受体激动剂,ICS+LABA),哮喘达到完全控制,在降级治疗前,进行肺通气功能检查；依据FEF75是否恢复正常,将入选患儿分组,比较患儿降级治疗后哮喘控制状况.结果 FEF75恢复正常组较FEF75未恢复组降级治疗后,哮喘完全控制率增高,部分控制、未控制率明显降低(x2=12.89,P均＜0.05)；在取消LABA的降级治疗前,如FEF75未恢复正常者,未控制率明显升高(x2=8.65,P＜0.05)、结论 FEF75可作为中、重度哮喘儿童能否顺利给予降级治疗的一个良好的客观指标.