目的分析母亲孕期糖代谢状况对其早产儿早期胰岛功能的影响，并探讨监测早产儿早期胰岛功能的敏感指标。方法将2012年3月至12月入住新生儿重症监护病房的82例早产儿分为2组，母亲孕期糖代谢异常组（35例）和母亲孕期糖代谢正常组（47例），分别检测早产儿生后1 h和7 d的空腹血糖（FPG）、胰岛素（FINS）、C-肽和胰岛素原，并比较早产儿胰岛β细胞功能的相关指数。结果两组早产儿母亲的孕前和产前体质指数（BMI）、早产儿出生时体质量和头围的差异均有统计学意义（P<0.05），但母亲孕体质量期增加的差异无统计学意义（P>0.05）。两组早产儿出生时胰岛素原与生后7 d的C-肽、胰岛素原的差异有统计学意义（P<0.05）。两组早产儿胰岛素抵抗指数（IR）、空腹β细胞功能指数（FBCI）和胰岛素敏感指数（IAI）的差异无统计学意义(P>0.05)。结论母亲孕期糖代谢异常并不影响早产儿早期胰岛功能，但早产儿早期胰岛素原的分泌已受影响。%Objectives To analyze the impact of glucose-insulin metabolism during pregnancy onβ-cell function in premature infant, and to explore biomarkers for monitoringβ-cell function in preterm infant. Methods Eighty-two premature infants admitted to NICU from March to December 2012 were divided into 2 groups, a group with abnormal maternal glucose metabolism during pregnancy (35 cases) and another group with normal maternal glucose metabolism during pregnancy group (47 cases). Fasting blood glucose, insulin, C-peptide and proinsulin at 1 hour after birth and 7 days postpartum were measured respectively, and relevant indices ofβ-cell function were compared in premature infants. Results Maternal pre-pregnancy and prenatal body mass index, weight and head circumference of preterm infants at birth were signiifcantly different between two groups (P<0.05) except for maternal weight gain in pregnancy (P>0.05). The differences in levels of proinsulin at birth, C-peptide and proinsulin at postnatal day 7 were signiifcantly different between the two groups (P<0.05). There was no signiifcant diffe-rence in insulin resistance, fastingβcell function index and insulin sensitivity index between two groups (P>0.05). Conclusions Abnormal maternal glucose metabolism in pregnancy has no effect on early pancreatic islet function in premature infant, how-ever, proinsulin secretion has been affected.
展开▼
