Objective To compare visual function after the standard laser in situ keratomileusis (LASIK) and wavefront aberration guided customized laser in situ keratomileusis (wavefront LASIK). Methods Sixty patients (120 eyes, Diopter - 3. 25 - - 10. 00 D) that needed refractive surgeries were recruited into two groups; wavefront-guided LASIK group (60 eyes) and the standard group (60 eyes). Comeal topography, bright and dark environment contrast sensitivity, and wavefront aberration (VISX) were examined preoperatively and 1-month and 3-month postoperatively. Data were analyzed using SPSS17.0 statistical software. Results The visual acuity in the two groups significantly improved after treatment. Contrast sensitivity was higher in wavefront group than in standard group at all frequencies, regardless the bright/dark environment or glare/no glare conditions. Aberrations fluctuated in both groups early after treatment. In dark environment, pass rate was higher in wavefront group than in standard group. This difference was more prominent in a glare condition. Comeal topography was mostly homogeneous at all postoperative stages in both groups. Wavefront group demonstrated a higher shape ratio than standard group did. Conclusion Compared with standard LASIK, wavefront guided LASIK has advantages in postoperative visual quality.%目的 比较常规准分子激光原位角膜磨镶术(常规LASIK)和波前像差引导的个体化准分子激光原位角膜磨镶术(波前LASIK)术后视功能状况.方法 选取接受手术者共60例(120只眼),屈光度-3.25～-10.00 D.随机分为两组:常规组30例(60只眼)和波前组30例(60只眼).常规组接受常规LASIK；波前组接受波前像差引导LASIK.患者于术前,术后1个月、3个月行明、暗环境下对比敏感度仪、波前像差仪和角膜地形图检查.应用SPSS17.0统计学软件进行统计.结果 视力:两组在术后均比术前显著改善.对比敏感度:术后明、暗环境条件下,眩光或者无眩光条件下,波前组的对比敏感度在各个频率都高于常规组.总体相差:术后早期两组像差数据均存在波动.在暗环境下,波前组的通过率高于常规组,有眩光条件下更为明显.角膜地形图:术后不同时间两组角膜形态主要为均匀形,而波前组规则形比例高于常规组.结论 与常规LASIK相比,波前像差引导的LASIK术后视觉质量优势显著.
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