妊娠高血压症患者FIB、D-二聚体及MMP-9与视网膜中动脉血流动力学参数相关性分析

摘要

目的 探讨妊娠高血压症患者纤维蛋白原(FIB)、D-二聚体及细胞基质金属蛋白酶-9(MMP-9)与视网膜中央动脉(CRA)血流动力学参数(PSV、EDV、RI)之间的相关性.方法 分析2015年1月至2016年5月在我院接受治疗的46例妊娠期高血压患者的临床资料,并列为观察组,51例健康孕妇作为对照组.结果 观察组患者CRA血流动力学PSV、EDV明显低于对照组,观察组CRA中RI指数明显高于对照组,差异均具有统计学意义(P<0.05),随着观察组患者病情的加重,RI呈现逐渐升高的趋势,PSV、EDV则降低(P<0.05);观察组患者FIB、D-二聚体及MMP-9水平明显高于对照组,差异均具有统计学意义(P<0.05);观察组患者FIB、D-二聚体、MMP-9与CRA RI指数呈现正相关关系(P<0.05).结论 CRA血流动力学指标及FIB、D-二聚体、MMP-9检测可作为妊娠高血压症早期诊断指标,具有一定的临床价值.%Objective To investigate the correlation of serum FIB, D-dimer and MMP-9 to retinal central artery (CRA) hemodynamic parameters in pregnancy induced hypertension patients.Methods We analyzed clinical data of 46 pregnancy-induced hypertension syndrome patients who were treated in our hospital between January 2015 and May 2016, and of 51 healthy pregnant women.Results PSV and EDV of the CRA in pregnancy-induced hypertension patients were significantly lower than those in control group, and RI was significantly higher than in control group.These differences were statistically significant (P<0.05).With the progression of the disease, RI gradually increased while EDV and PSV decreased (P<0.05).The levels of FIB, D-dimer and MMP-9 were significantly higher in patients (P<0.05), and these biomarkers showed a positive correlation with RI (P<0.05).Conclusions Hemodynamic parameters of the CRA were correlated to serum FIB, D-dimer and MMP-9.CRA hemodynamic parameters can be used as early diagnostic indicators of pregnancy-induced hypertension.