鸦胆子油乳剂联合放疗治疗脑恶性胶质瘤的疗效观察

摘要

Objective To evaluate the clinical efficacy and safety of brucea javanica oil emulsion in the treatment of malignant brain glioma.Methods 33 patients with brain gliomas after surgery were randomly divided into observation group(Brucea javanica oil emulsion plus radiotherapy) and control group( temozolomide plus radiotherapy ) .Observation and comparison of two groups of patients with clinical curative effect,1 year,2 year survival rate,toxic side effects as well as the improvement of the quality of life.Results In the observation group and the control group of patients with treatment of recent efficiency were 58.8% and 62.5%,no statistical significance ( P=1.000).1 years,2 year survival rate were no significant difference.The observation group Karnofsky scores improvement and in the control group(P<0.05).Observed the adverse reactions of the two groups total incidence rate was lower than the control group(P<0.05).Conclusions Brucea javanica oil emulsion combined with radiotherapy is a safe and effective therapy for malignant glioma patients.%目的：探讨鸦胆子油乳剂治疗脑胶质瘤的临床效果及安全性。方法随机将33例脑胶质瘤术后患者分为观察组（鸦胆子油乳剂＋放疗）和对照组（替莫唑胺＋放疗）。观察和比较两组患者的临床疗效，1年、2年生存率，毒副反应的发生情况以及生活质量的改善情况。结果观察组和对照组患者的治疗近期有效率分别为58．8％和62．5％，差异无统计学意义（P＝1．000）。1年、2年生存率无显著差异。观察组卡氏评分的改善情况优于对照组（P＜0．05）。观察组不良反应的总发生率低于对照组（P＜0．05）。结论鸦胆子油乳剂联合放疗对胶质瘤术后患者具有一定的治疗价值。