帕金森病患者血小板5-羟色胺水平的改变及其与抑郁、认知功能障碍的关系

摘要

目的 探讨帕金森病(PD)患者血小板5-羟色胺(5-HT)水平的改变及其与抑郁、认知功能障碍的关系.方法 采用高效液相色谱法检测54例PD患者和54名健康中老年人(正常对照组)的血小板5-HT水平.采用汉密尔顿抑郁(HAMD)量表和简易精神状态检查(MMSE)量表对PD患者进行评分,并对血小板5-HT水平与HAMD和MMSE量表评分进行相关性分析.结果 PD患者血小板5-HT水平比正常对照组显著降低(P<0.05),并且PD伴抑郁、认知功能障碍患者的血小板5-HT水平分别显著低于PD无抑郁及无认知功能障碍患者(均P<0.05).PD患者血小板5-HT水平与HAMD量表评分呈负相关(r=-0.3310,P<0.05),与MMSE量表评分呈正相关(r=0.5415,P<0.05);PD伴抑郁患者的MMSE量表评分显著低于无抑郁患者(P<0.05).结论 PD患者的血小板5-HT水平明显降低,并且PD伴抑郁和认知功能障碍患者的血小板5-HT水平降低更明显.%Objective To investigate the change of the level of platelet 5-hydroxytryptamine(HT) and its correlation with depression and cognitive dysfunction in patients with Parkinson disease(PD).Methods The levels of platelet 5-HT was measured in 54 PD patients and 54 healthy aged and elderly people ( normal control group) by high performance liquid chromatography.PD patients were measured by Hamilton depression rating scale (HAMD) and Mini-mental state examination (MMSE) scale.The correlation analyed between the level of platelet 5-HT and HAMD, MMSE.Results The level of platelet 5-HT in PD group was significantly lower than that in normal control group(P ＜ 0.05 ), and the level of 5-HT in PD patients with depression or cognitive dysfunction was significantly lower than that in PD patients without depression or cognitive dysfunction( all P ＜0.05 ).The level of platelet 5-HT was negative correlation with HAMD score(γ = -0.3310 ,P ＜0.05 ), and positive correlation with MMSE score(r= 0.5415 ,P ＜ 0.05).The MMSE score in PD patients with depression was significantly lower than that in PD patients without depression(P ＜ 0.05 ).Conclusion The level of platelet 5-HT in PD patient is decreased significantly,which even lower in PD patients with depression and cognitive dysfunction.