短暂性脑缺血发作患者脑默认状态网络连通性的改变

摘要

Objective To investigate the changes of brain default-mode network ( DMN) connectivity in patients with transient ischemic attack (TIA). Methods Sixteen interictal TIA patients and 16 normal controls were underwent with functional MR scan. The regions of interest (ROI) were set on the cingulate/precuneus and ventral anterior cingulate/medial prefrontal, and the average time signal in which were extraction. The connectivity of brain regions connected with ROI was analyzed. Results Compared with the normal control group, the functional connectivity in TIA group was reduced on left anterior cingulate gyms and hippocampus, right anterior frontal gyrus, insular lobe, precuneus and inferior parietal lobule; and which enhanced on right cerebellum, thalamus and caudate nucleus. Conclusions The brain DMN is abnormal in TIA patients. The connectivity of part brain region reduced. The connectivity increased on thalamus and cerebellum may be the compensation of brain function or protective response.%目的 探讨短暂性脑缺血发作(TIA)患者脑默认状态网络(DMN)连通性的改变.方法 对16例发作间期TIA患者和16名正常对照者进行功能MR检查,以扣带回/楔前叶及腹侧扣带前回/内侧前额叶作为感兴趣区(ROI),提取ROI内部平均时间信号,分析与ROI连通脑区的功能连通性.结果 与正常对照组比较,TIA组DMN功能连通性减弱的脑区有左侧扣带前回及海马,右侧额前回、岛叶、楔前叶及顶下小叶；功能连通性增强的脑区主要存在于右侧小脑、丘脑及尾状核.结论 TIA患者脑DMN异常,部分脑区的功能连通性减弱；而丘脑、小脑功能连通性增强可能是脑的代偿或保护性反应.