奥美拉唑预防急性心肌梗塞发生应激性溃疡的临床研究

摘要

目的 观察行PCI术及氯吡格雷治疗的急性心肌梗死患者联用奥美拉唑情况,比较不同组别应激性溃疡的发生率,为急性心肌梗死患者预防应激性溃疡合理用药提供临床研究依据.方法 本研究共纳入急性心肌梗死成功行PCI术的患者306例,按照使用奥美拉唑情况分为2组:非PPIs组154例、PPIs组152例,比较2组患者住院期间应激性溃疡消化道出血事件的发生率.结果 2组患者住院期间应激性溃疡发生率及消化道大出血发生率有显著差异(P＜0.05).结论 急性心肌梗死患者在病程早期(1周内)及时联用质子泵抑制剂(奥美拉唑)可以有效预防发生应激性溃疡引起的消化道出血,尤其是消化道大出血的发生.%Objective To observe the condition of patients with acute myocardial infarction (AMI) treated by PCI operation and clopidogrel combined with omeprazole, and compare the incidence rate of stress ulcers in different groups in order to provide clinical evidence for rational application of omeprazole for preventing stress ulcers in AMI patients. Methods 306 AMI patients underwent PIC operation were selected and divided into 2 groups according to the application amount of omeprazole. Non-PPIs group (154 cases) and PPIs group (152cases). The incidence rate of digestive tract haemorrhage induced by stress ulcers during hospitalization were compared between 2 groups. Results The incidence rate of stress ulcers and incidence rate of digestive tract haemorrhage had significant differences in both of 2 groups (P<0.05). Conclusion In the early period of AMI (within 1 week), timely application of proton pump inhibitors (omeprazole) can effectively prevent digestive tract haemorrhage induced by stress ulcers, especially massive haemorrhage of digestive tract.