葛根素对冠心病患者血浆内皮素和一氧化氮水平及心肌缺血的疗效探讨

摘要

Objective To investigate the clinical efficacy of puerarin on plasma endothelin, nitric oxide levels and myocardial ischemia of patients with coronary heart disease. Methods Sixty -eight patients with coronary heart disease were randomly divided into puerarin group (n = 34) and control group (n = 34). The control group received isosorbide mononitrate tablets and the puerarin group received puerarin in addition to the conventional therapy for the control group. After treatment, the changes of TIB, VPBs, HR, SP, ICE, plasma ET and NO in the two groups were observed. Follow-up was conducted twice a day. The frequency of angina attack and nitroglycerin consumption were recorded. Results After treatment, the frequency of angina attack and nitroglycerin consumption decreased significantly (P<0.01). The puerarin group had more significant improvement than the control group (P<0.01). After treatment, plasma ET decreased significantly (P< 0.01). Plasma NO levels increased significantly (P<0. 01). After treatment, plasma ET and NO in the puerarin group had more significant increase than those in the control group (P<0.01) . After treatment, the TIB, SP, ICE and VPBs levels in the two groups decreased significantly (P<0. 01). After treatment, the TIB and VPBs levels were significantly lower in the puerarin group than in the control group (P<0.01). Conclusion Puerarin can improve vascular endothelial cell function in patients with coronary heart disease, and effectively regulate the plasma ET and HO levels, which is an effective drug for myocardial ischemia induced by coronary heart disease.%目的 探讨葛根素对冠心病患者血浆内皮素和一氧化氮水平及心肌缺血的临床疗效.方法 68例冠心病患者随机分为葛根素组和对照组,每组34例.对照组给予硝酸异山梨酯片;葛根素组在对照组常规治疗基础上加用葛根素.观察2组患者治疗前后动态心电图检测心肌缺血总负荷(TIB)、室性期前收缩(VPB)、心率(HR)、收缩压(SP)、和心肌耗氧指数(ICE)变化情况;血浆血浆内皮素(ET)、一氧化氮(NO)水平;每日随访2次,记录患者心绞痛发作次数及硝酸甘油消耗量.结果 2组治疗后心绞痛发作次数及硝酸甘油耗量均较治疗前有不同程度的减少,葛根素组较对照组改善明显(P＜0.01).与治疗前比较,2组治疗后血浆ET水平均显著降低(P＜0.01),血浆NO水平显著升高(P＜0.01);与对照组治疗后比较,葛根素组治疗后血浆ET、NO水平变化更加明显(P＜0.01).与治疗前比较,2组治疗后TIB、SP、ICE、VPB水平均较治疗前明显降低(P＜0.01);葛根素组治疗后TIB、VPB水平明显低于对照组治疗后(P＜0.01).结论 葛根素可改善冠心病患者血管内皮细胞功能,能有效调节CAD患者血浆ET和NO水平,是一种有效治疗冠心病心肌缺血的药物.