黄芪防芷汤对变应性鼻炎患者血清IgE,IL-4,IL-12含量的影响

摘要

目的 探讨黄芪防芷汤在变应性鼻炎治疗中的作用.方法 68例变应性鼻炎患者随机分为对照组和治疗组,各34例.对照组应用布地奈德,孟鲁司特,酮替芬治疗.治疗组在对照组治疗基础上,服用自拟中药方.观察2组患者治疗前后血清IgE、IL-4、IL- 12水平、变应性鼻炎症状评分、气道反应性.结果 2组患者治疗后血清IgE、IL -4水平较均较治疗前明显降低(P＜0.05),IL- 12水平较治疗前明显升高(P＜0.05)；治疗组治疗后IL-4水平明显低于对照组治疗后(P＜0.05),IL- 12水平明显高于对照组治疗后(P＜0.05).治疗组治疗后变应性鼻炎症状评分明显低于对照组治疗后(P＜0.05).2组治疗后Fres、R5及R20均较治疗前明显降低(P＜0.05),治疗组较对照组降低的更加明显(P＜0.05).结论 黄芪防芷汤治疗变应性鼻炎疗效可靠,其治疗作用可能与纠正患者体内Th1/Th2平衡状态有关.%Objective To investigate the influence of Astragalus Anti - Chih Tang in patients with allergic rhinitisin. Methods Sixty - eight patients with allergic rhinitis were randomly divided into control group (n =34) and treatment group (n =34). The control group received budesonide,montelukast,and ketotifen. Based on the therapy of the control group,the treatment group received self - prescribed treatment. The serum levels of IgE,IL - 4 and IL - 12,allergic rhinitis symptom score and airway reactivity were observed before and after treatment. Results After treatment,the serum IgE,IL -4 levels in two groups were significantly lower (P<0.05). IL - 12 level was significantly higher (P< 0.05). IL-4 level in the treatment group was significantly lower than that in the control group (P<0. 05),and IL- 12 level was significantly higher than that in the control group ( P < 0.05). After treatment,the allergic rhinitis symptoms score in the treatment group was significantly lower than that in the control group (P<0. 05). The Fres,R5 and R20 in the treatment group were significantly lower (P<0. 05) and the treatment group decreased more significantly than the control group (P < 0. 05). Conclusion Astragalus Anti - Chih Tang has reliable efficacy in the treatment of allergic rhinitis. Its therapeutic effect may be related to Thl/Th2 which corrects the balance of the patient s body.