地佐辛和吗啡用于乳腺癌根治术后静脉镇痛的效果比较

摘要

Objective To observe the effects of intravenous analgesia with dezocine and morphine in patients with radical mastectomy of breast cancer. Methods A total of 60 patients undergoing radical mastectomy of breast cancer( ASA I --II) were recruited and divided into morphine group (group M, n = 30) and dezocine group (group D, n = 30). Patient controlled intravenous analgesia (PICA) lasted for 48 h. Peripheral venous blood was drawn before induction and at 1, 3, 24 h after operation. Serum levels of |3 - EP were measured with radioimmunoassay. Results There was no significant statistical significance among the two groups in visual analog scale (VAS) and the serum levels of P - EP (P >0. 05). Conclusion Morphine and dezocine can inhibit the stress response and analgesia effectively.%目的 观察地佐辛用于乳腺癌根治术后的静脉镇痛效果.方法 选择60例拟全麻下行乳腺癌根治手术的患者,ASAⅠ、Ⅱ级,随机分为吗啡组(M组)和地佐辛组(D组),每组30例.术毕开始术后镇痛,持续48 h.分别于麻醉前、术毕及术后1、3、24 h采血,应用放射免疫分析法检测血清β-内啡肽(β- EP).结果 两组患者镇痛评分(VAS)、β-EP水平差异均无统计学意义(P＞0.05).结论 吗啡和地佐辛均可有效抑制术后应激反应,镇痛效果确切,适合用于术后镇痛.