调脂联合降压治疗对动态血压及血压变异性的影响

摘要

Objective To investigate the impact of lipid-lowering drug simvastatin and antihypertensive drug nifedipine ambulatory blood pressure in patients with hypertension and blood pressure variability.Methods A total of 226 patients were diagnosed as hypertension patients,divided into two groups according to the hospitalized random number in each group,113 cases in the control group treated with nifedipine antihypertensive therapy and 113 cases in the treatment group applied with combined simvastatin treatment.All patients before treatment and after treatment underwent lipids and ambulatory blood pressure checks,the 24h average systolic blood pressure and mean diastolic blood pressure changes were recorded,and the mean standard deviation and 24h dynamic pulse pressure were calculated and compared before and after treatment in patients with hyperlipidemia and ambulatory blood pressure values and their stability.Results After the end of treatment,the lipid levels of the observation group were significantly lower than those of the control group (P＜0.01).24hPP and SBPV of the observation group,compared with the control group,decreased significantly,the difference being significant (P ＜ 0.05).DBPV levels of the observation group patients decreased significantly before treatment,the difference being statistically significant (P＜ 0.05).And after the end of treatment,the observation group was compared with the control group after treatment:the 24hSD,dSSD,dDSD,nSSD significantly was lower,and the difference was statistically significant (P ＜ 0.01).Conclusion Lipid-lowering drug combination antihypertensive drugs can further smooth hypertension,and is worth clinical application.%目的 探讨调脂药辛伐他汀联合降压药硝苯地平对高血压患者动态血压及血压变异性的影响.方法 226例诊断为高血压病的患者,按入院随机号分为2组,每组各113例,对照组单纯给予硝苯地平进行降压治疗;观察组在此基础上联合辛伐他汀进行治疗;所有患者均于治疗前及治疗后行血脂及动态血压检查,记录24 h平均收缩压及平均舒张压变化,并计算其均数标准差和24 h动态脉压,比较2组患者治疗前后血脂及动态血压值及其稳定性的变化.结果 疗程结束后,观察组患者血脂水平明显低于对照组(P＜0.01); 24 h缩小脉压(PP)及收缩压血压变异性(SBPV)较对照组下降明显,2组比较差异有统计学意义(P＜0.05).观察组患者舒张压血压变异性(DBPV)水平较治疗前明显下降,差异有统计学意义(P＜0.05);且疗程结束后,观察组与对照组治疗后比较:24hSD、dSSD、dDSD、nSSD明显降低,差异有统计学意义(P＜0.01).结论 调脂药联合降压药可进一步提高血压的平稳性,值得临床广泛推广应用.