阿托伐他汀强化治疗对急性冠脉综合征患者血脂及血清超敏C-反应蛋白、基质金属蛋白酶-9水平的影响

摘要

Obj ective To explore the influence of atorvastatin intensive treatment on blood lipid and the level of serum high-sensitivity C-reactive protein (hs-CRP )and matrix metallopro-teinase (MMP-9)in patients with acute coronary syndrome (ACS).Methods A total of 131 pa-tients with ACS performed with percutaneous coronary intervention (PCI )in our hospital were se-lected and randomly divided into 2 groups,namely conventional group (63 cases )and intensive group (68 cases).Conventional group was given atorvastatin conventional treatment while intensive group was given atorvastatin intensive treatment.After 4 weeks,the level of blood lipid hs-CRP and MMP-9 and the occurrence of adverse reactions were recorded and the conditions of prognosis were observed.Results After 4 weeks,the levels of total cholesterol,triglyceride,low density lipoprotein,hs-CRP and MMP-9 in intensive group were lower than treatment before and control group (P<0.05,or P<0.01).High-density lipoprotein was significantly higher than treatment before and conventional group (P<0 .0 1 ).There was no adverse reactions in conventional group but slighter in intensive group,with good tolerance.At the end of the follow-up,the prognosis of intensive group was superior to conventional group (P<0 .05 ).Conclusion Compared with con-ventional treatment,atorvastatin intensive treatment has an better effect on ACS,capable of obvi-ously improving the clinical benefit of patients.%目的：探讨阿托伐他汀强化治疗对急性冠脉综合征（ACS）患者血脂及血清超敏C-反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）水平的影响。方法选取本院治疗的131例行冠脉介入治疗（PCI）的ACS患者，随机分为2组：常规组63例，采用阿托伐他汀常规治疗方案；强化组68例，采用阿托伐他汀强化治疗方案。治疗4周后，记录2组治疗前后血脂、hs-CRP、MMP-9水平变化及不良反应发生情况。至随访截止，观察2组预后情况。结果治疗4周后，强化组总胆固醇、甘油三酯、低密度脂蛋白、hs-CRP、MMP-9水平显著低于治疗前及常规组（P＜0．05或P＜0．01），高密度脂蛋白显著高于治疗前及常规组（P＜0．01）。常规组未见明显不良反应，而强化组不良反应轻微，患者耐受性好。至随访结束，强化组预后情况显著优于常规组（P＜0．05）。结论与常规治疗相比，阿托伐他汀强化治疗ACS的疗效更优，能显著提高患者的临床获益。