结直肠癌患者血清中高表达白介素22与FOLFOX 化疗抵抗的相关性

摘要

目的：检测血清中 IL-22与 FOLFOX 化疗抵抗的相关性，并通过体外细胞试验探究 IL-22能否促进结直肠癌细胞系产生化疗抵抗。方法通过 ELISA 法检测60例根治术后接受 FOLFOX 化疗的结直肠癌患者外周血清 IL-22表达；通过细胞增殖试验检测 IL-22对化疗药物作用下细胞增殖率的影响。结果IL-22在化疗抵抗患者血清中的表达量明显高于化疗敏感患者。IL-22能够促进结直肠癌细胞系 SW480和 SW620对5氟尿嘧啶和奥沙利铂的化疗抵抗。结论IL-22与 FOLFOX化疗抵抗状态明显相关，可作为参与化疗抵抗的重要因素之一。%Objective To explore the correlation between IL-22 expression levels in serum and FOLFOX resistant status and to examine weather IL-22 could promote chemoresistance in colorec-tal cancer cells.Methods ELISA were preformed to detect IL-22 expression levels in 60 patients who received FOLFOX adjuvant chemotherapy after radical excision.The chemoresistant effect of IL-22 in colorectal cancer cells with treatment of chemotherapeutic drugs was investigated.Results IL-22 serum levels increased in chemoresistant patients compared with chemosensitive patients.In addi-tion,IL-22 could confer resistance to 5-FU and OXA of SW480 and SW620 cell lines.Conclusion Elevated serum IL-22 levels correlate with FOLFOX chemoresistant condition of colorectal cancer and may be an important factor for chemoresistance.