血小板参数在成人重度原发免疫性血小板减少症诊断和疗效判断中的意义

摘要

Objective To explore the clinical significance of detecting platelet parameters in the diagnosis and efficacy-evaluation of adult severe primary immune thrombocytopenia (ITP). Methods Thirty-four adult patients with primary ITP admitted in our hospital served as observa-tion group while another 30 healthy people undergoing physical examination as control group. Platelet parameters on both groups before treatment and in observation group 3and 7 days after treatment were observed.Results Before treatment,observation group was evidently lower in platelet count (PLT)and plateletocrit (PCT)and obviously higher in mean platelet volume (MPV) than control group (P <0.05),but there was no significant difference in platelet distributive width (PDW)(P >0.05).Compared with treatment before,PLT,PCT,MPV increased more markedly 3 d after treatment while PLT,PCT,PDW increased significantly 7 days after treatment in obser-vation group (P <0.05).Conclusion Platelet parameters have important clinical significance in e-valuating the progression and efficacy of adult patients with severe primary ITP.%目的：探讨血小板参数的检测在成人重度原发免疫性血小板减少症（ITP）诊断和疗效判断的临床意义。方法选取本院收治的34例原发重度 ITP 患者为观察组，另选取30例本院同期健康体检者为对照组。记录2组治疗前和观察组治疗3、7 d 后血小板参数值。结果治疗前，观察组血小板计数（PLT）、血小板比积（PCT）显著低于对照组（P ＜0．05），平均血小板体积（MPV）明显高于对照组（P ＜0．05），而血小板分布宽度（PDW）无明显差异（P ＞0．05）。与治疗前比较，观察组治疗3 d 后 PLT、PCT、MPV 均明显增加（P ＜0．05），治疗7 d 后 PLT、PCT、PDW 均有显著增加（P ＜0．05）。结论血小板参数对判断重度原发 ITP 患者病情进展和疗效均有重要临床意义。