不稳定型心绞痛患者血清内脏脂肪素水平的变化及与血管内皮细胞黏附分子的相关性

摘要

目的 观察和分析不稳定型心绞痛(UA)患者血清内脏脂肪素(Visfatin)水平的变化及与血管内皮细胞黏附分子的相关性.方法 选取100例UA患者、100例稳定型心绞痛(SA)患者及50名健康志愿者作为研究对象,分别设为UA组、SA组及对照组.对3组研究对象的血清Visfatin、可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性细胞间黏附分子1(sICAM-1)水平进行检测和比较.结果 UA组患者的血清Visfatin、sVCAM-1、sICAM-1水平均显著高于SA组或对照组(P<0.05).直线相关分析结果显示,UA组患者的血清Visfatin水平与体质量指数(BMI)、腰围、甘油三酯(TG)水平、sVCAM-1、sICAM-1水平均具有相关性(P<0.05).多元线性回归结果显示,UA组患者血清Visfatin水平与腰围、sVCAM-1、sICAM-1水平具有相关性(P<0.05).结论 UA患者表现为血清Visfatin水平的显著上升,其水平与血清sVCAM-1、sICAM-1水平具有相关性.%Objective To observe and analyze the change of serum visceral fatin(Visfatin)level in the patients with unstable angina(UA)and its correlation with the vascular endothelial cell adhesion molecule level.Methods Totally 100 UA patients,100 patients with stable angina(SA)and 50 healthy volunteers were selected as UA group,SA group and the control group.The serum Visfatin,the soluble vascular cell adhesion molecule-1(sVCAM-1),the soluble intercellular adhesion molecule 1(sICAM-1)levels in the three groups were detected and compared.Results The serum Visfatin,sVCAM-1,sICAM-1 levels of the patients in UA group were significantly higher than those in SA group or the control group(P<0.05).Linear correlation analysis showed that the serum Visfatin level of the patients in UA group was correlated with body mass index(BMI),the waist circumference,the triglyceride(TG)level,sVCAM-1,sICAM-1 levels(P<0.05).Multiple linear regression analysis showed that the serum Visfatin level of the patients in UA group was correlated with sVCAM-1,sICAM-1 level and the waist circumference(P<0.05).Conclusion Serum Visfatin level significantly increases in the patients with UA,and Visfatin level is correlated with the serum sVCAM-1 and sICAM-1 levels.