早期应用西酞普兰对急性皮质脑梗死患者运动功能恢复的影响

摘要

目的 探讨西肽普兰对急性皮质脑梗死患者早期运动功能恢复的影响.方法 选择急性皮质脑梗死患者276例.按照随机数字法将患者分为观察组和对照组各138例.对照组患者给予抗血小板、降脂、保护神经和康复治疗等.观察组在对照组治疗的基础上给予氢溴酸西肽普兰片.结果 观察组卒中后抑郁患病率为18.1％,显著低于对照组的42.7％(P＜0.05).治疗后,观察组HDRS评分和NIHSS评分显著低于对照组(P＜0.05).观察组患者治疗30、90 d后FMA手运动功能评分较基线分别增高4.1±1.0分和6.5±2.5分,显著高于对照组的1.4±0.7分和2.5±1.5分(P＜0.05).观察组患者治疗30 d后BI评分显著高于对照组(P＜0.05).结论 早期应用西肽普兰治疗急性皮质脑梗死患者能显著降低患者卒中后抑郁的发生率,促进患者运动功能的恢复,提高患者的预后质量.%Objective To explore the influence of citalopram on early recovery of motor function in patients with acute cortical infarction.Methods A total of 276 patients with acute cerebral infarction were randomly divided into observation group and control group,138 cases in each group.Patients in control group were treated with anti-platelet,blood lipid,protective nerve and rehabilitation therapy.The observation group was given citalopram hydrobromide tablets on the basis of control group.Results The incidence rate of depression in the observation group was 18.1％,which was significantly lower than 42.7％ in the control group (P ＜ 0.05).After treatment,HDRS score and NIHSS score in the observation group were significantly lower than the control group (P ＜ 0.05).In the observation group,after treatment of 30 days and 90 days,the increasing scores of hand motor function of FMA were 4.1 ± 1.0 points and 6.5 ± 2.5 points,which were significantly higher than 1.4 ± 0.7 points and 2.5 ± 1.5 points (P ＜ 0.05).After treatment of 30 days,the BI score of observation group was significantly higher than control group (P ＜ 0.05).Conclusion Early application of citalopram can effectively reduce the incidence rate of post-stroke depression in patients with acute cerebral infarction,promote the recovery of motor function and improve the quality of prognosis.