外周血半乳糖凝集素-3、N末端B型利钠肽原在慢性心力衰竭患者中的表达及意义

摘要

目的 探讨慢性心力衰竭(CHF)患者外周血半乳糖凝集素(Gal)-3、N末端B型利钠肽原(NT-proBNP)表达水平的变化.方法 选择89例CHF患者,采用酶联免疫吸附法、电化学发光法分别检测入选患者外周血Gal-3、NT-proBNP表达水平,分析他们在不同类型心力衰竭、心功能分级患者中的变化.结果 HFPEF、HFREF患者Gal-3、NT-proBNP水平比较,差异均有统计学意义(P=0.000);心功能Ⅱ级、Ⅲ级、Ⅳ级患者Gal-3、NT-proBNP表达水平有显著差异(P =0.000);Gal-3与NT-proBNP呈正相关(r=0.230,P=0.030),与LVEF呈负相关(r=-0.533,P=0.000);NT-proBNP与LVEF呈负相关(r=-0.372,P=0.000).结论 外周血Gal-3、NT-proBNP可作为评判CHF患者病情危重程度的重要指标.%Objective To explore the change of peripheral galectin (Gal)-3 and N-terminal B-type brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure.Methods A total of 89 patients with chronic heart failure (CHF) were enrolled.Peripheral Gal-3,NT-proBNP were detected by enzyme-linked immunosorbent assay (ELISA) or Electrochemical luminescence method.The expression levels of Gal-3,NT-proBNP in patients with different kinds of heart failure and cardiac functional grading were analyzed.Results There were significant differences in expression levels of Gal-3 and NT-proBNP between patients with HFPEF and patients with HFREF.There was significant differences of Gal-3 and NT-proBNP in patients with NYHA heart function class Ⅱ,Ⅲ and Ⅳ.Gal3 was positively correlated with NT-proBNP (r =0.230,P =0.030) and negatively correlated with LVEF (r =-0.533,P =0.000).NT-proBNP was negatively correlated with LVEF (r =-0.372,P =0.000).Conclusion Peripheral Gal-3,NT-proBNP could be considered as two important markers for judging severity of illness in patients with CHF.