盐酸利托君对先兆早产患者血清Th1/Th2细胞因子及分泌物fFN、IGFBP-1、MMP的影响

摘要

目的 研究盐酸利托君对先兆早产患者血清Th1/Th2细胞因子及分泌物fFN、IGFBP-1、MMP的影响.方法 选取2013年2月-2015年4月在本院进行治疗的68例先兆早产患者为研究对象,将其随机分为对照组34例和观察组34例,比较2组患者治疗前和治疗后的血清Th1/Th2细胞因子及分泌物fFN、IGFBP-1、MMP水平.结果 治疗前,2组的血清Th1/Th2细胞因子及分泌物fFN、IGFBP-1、MMP水平均无显著差异(P＞0.05),而治疗后不同时间观察组以上指标均显著优于对照组(P＜0.05).结论 盐酸利托君对先兆早产患者的血清Th1/Th2细胞因子及分泌物fFN、IGFBP-1、MMP表达有积极的改善作用,因此对于此类孕妇的应用价值较高.%Objective To study the influence of ritodrine hydrochloride on the serum Th1/ Th2 cytokine and secretion fFN,IGFBP-1,MMP of patients with premature labor.Methods A total of 68 patients with premature labor in our hospital from February 2013 to April 2015 were selected as the research objects,and were randomly divided into control group (n =34) and observation group with (n =34),then the serum Th1/Th2 cytokines and secretion fFN,IGFBP-1,MMP of two groups were compared.Results The serum Th1/Th2 cytokines and secretion fFN,IGFBP-1,MMP of observation group had no significant differences(P ＞ 0.05),while the levels of above indicators in the observation group at different time after the treatment were better than that of control group,and the differences were significant (P ＜ 0.05).Conclusion The ritodrine hydrochloride can actively improve the expression of serum Thl/Th2 cytokine and secretion fFN,IGFBP-1,MMP of patients with premature labor,so it's of great value for the pregnant women.