改良folfox6与SOX方案在进展期胃癌新辅助化疗中的疗效比较

摘要

目的 比较改良folfox6与SOX方案在进展期胃癌新辅助化疗中的疗效.方法 选取进展期胃癌患者82例,随机分为A组和B组,各41例.A组采用SOX化疗方案,B组采用改良folfox6化疗方案.比较2组近期疗效、生活质量改善情况、毒副反应发生情况及中位疾病进展时间和生存时间.结果 A组近期总有效率、生活质量提高率显著高于B组(P＜0.05),中性粒细胞和血小板减少发生率显著低于B组(P＜0.05),而2组骨髓抑制、恶心、呕吐、腹泻和乏力发生率比较无显著差异(P＞0.05);A组中位疾病进展时间和生存时间显著长于B组(P＜0.05).结论 SOX方案治疗进展期胃癌的近期疗效、生活质量改善优于改良folfox6方案,部分毒副反应轻于改良folfox6方案.%Objective To compare efficacy of modified folfox6 plan and SOX plan in treatment of advanced gastric cancer patients with neoadjuvant chemotherapy.Methods Totally 82 patients with advanced gastric cancer were randomly divided into group A and group B,41 cases in each group.Group A was treated with SOX chemotherapy scheme,and group B was treated with modified folfox6 chemotherapy scheme.The short-term efficacy,quality of life,side effects,median disease progression and survival time were compared between the two groups.Results In group A,the short-term effective rate and improvement rate of the quality of life were significantly higher than group B (P ＜ 0.05),while incidence rate of neutropenia and thrombocytopenia were significantly lower than group B (P ＜ 0.05),while the incidence rates of bone marrow suppression,nausea and vomiting,diarrhea and fatigue rate showed no significant differences (P ＞ 0.05).In group A,median time to progression and survival time were significantly longer than group B (P ＜ 0.05).Conclusion The SOX regimen is better than the modified folfox6 regimen in the treatment of advanced gastric cancer,and the improvement of life quality is better than the modified folfox6 regimen.