METHOD FOR PREDICTING EFFECTIVENESS OF POSTOPERATIVE ASSISTANT CHEMOTHERAPY IN SURGICALLY REMOVED PROGRESSIVE STOMACH CANCER

摘要

PPROBLEM TO BE SOLVED: To provide a method for predicting effectiveness of an anticancer agent to make postoperative chemotherapy using tegafur-gimeracil-oteracil potassium combination S-1 for preventing recurrence in a patient of surgically removed progressive stomach cancer more effective, and to establish therapy suitable for the patient individual, and to provide a reagent and a kit usable for the method. PSOLUTION: The method for predicting the effectiveness of the postoperative assistant chemotherapy using the S-1 in the patient of the surgically removed progressive stomach cancer includes measuring the expression level of a thymidylate synthase (TS) gene contained in a sample containing a cancer cell collected from the patient, and predicting the effectiveness from the expression level. The reagent and the kit for measuring the expression level of the TS gene, for determining the effectiveness of the postoperative chemotherapy using the S-1 include a primer for amplifying the TS gene and/or a probe for the TS gene. PCOPYRIGHT: (C)2011,JPO&INPIT