不同麻醉方法对手术后小儿Toll样受体4表达及血清S100β蛋白水平的影响

摘要

Objective To explore the effects of different anesthesia methods on postoperative TLR4 expression and the level of serum S100β protein in children.Methods Totally 122 children with elective surgery were randomly divided into two groups.The control group was treated with ketamine intravenous anesthesia,while the observation group was treated with inhalation anesthesia with sevoflurane.Expression of TLR4,the level of serum S100β protein and the adverse reactions of anesthesia were observed.Results During the period of anesthesia,the incidence rates of physical and mental symptoms in the observation group were significantly lower than the control group (P ＜ 0.05).The levels of serun S100β protein at 2 h and 24 h after operation in the observation group were significantly lower than those in the control group (P ＜ 0.05).Compared with those before operation,there was no significant difference in the expression of TLR4 at the time of skin incision,2 h and 24 h after operation (P ＞ 0.05).The expressions of TLR4 at the time points of after skin incision,2 h and 24 h after operation in the control group were significantly lower than those before operation and the observation group (P ＜ 0.05).Conclusion The sevoflurane inhalation anesthesia can reduce the adverse reactions of anesthesia in children with surgery.%目的 探讨不同麻醉方法对小儿术后Toll样受体4(TLR4)表达及血清S100β蛋白水平的影响.方法 择期小儿外科手术患儿122例随机分成2组,对照组为氯胺酮静脉麻醉组,观察组为七氟烷吸入麻醉组.观察术后TLR4表达、血清S100β蛋白水平表达变化及麻醉不良反应.结果 麻醉期间,观察组体动、精神症状发生率显著低于对照组(P＜0.05).观察组术后2h、24 h血清S1003蛋白水平显著低于对照组(P＜0.05).与术前相比,观察组切皮时、术后2h及24 h的TLR4的表达无显著差异(P＞0.05);对照组切皮时、术后2h及24h的TLR4显著低于观察组及术前水平(P＜0.05).结论 对手术患儿采取七氟烷吸入麻醉方案的不良反应较少.