哮喘患者气道阻力变化对中枢驱动的影响

摘要

目的 了解哮喘患者气道阻力的变化对中枢驱动的影响。方法对13名正常人和21例哮喘患者作气道反应性测定，于激发试验前后分别测定吸气初0．1 s时口腔阻断压(P0．1)，其中10例哮喘患者激发试验后吸入喘乐宁，测定FEV1及P0．1。结果正常人9名(9／13)、哮喘患者19例(19／21例)组胺激发试验后P0．1较激发前显著升高，两组P0．1升高人数的百分比比较差异无显著性，哮喘患者激发后FEV1％与P0．1呈负相关(r＝-0．4576，P<0．05)，10例哮喘患者激发后吸入喘乐宁，FEV1较激发后显著上升，P0．1则显著下降。结论组胺诱导哮喘患者支气管收缩时，FEV1下降，P0．1上升，二者呈负相关，吸入支气管舒张剂后，FEV1上升．P0．1下降，表明中枢驱动受气道阻力的影响。%bjective To study the effect of change in airway resistance on central drive in pa-tients with asthma. Methods Bronchial provocation tests were done in 13 normal subjects and 21 pa-tients with asthma. The mouth occlusion pressures at 0. 1 second at the beginning of inspiration(P0. 1) were measured before and after provocation, while FEV1 and P0.1 were measured in 10 patientswho inhaled Artrovent after provocation. Results P0.1 increased significantly in 9 normal subjects(9/13) and 19 patients (19/21) after provocation test. FEV1 correlated negatively with P0. 1in pa-tients after provocation test ( r = -0. 4576, P <0.05). In 10 patients who inhaled Artrovent afterprovocation test, FEV1 and P0.1 significantly increased and decreased, respectively. Conclusion Cen-tral drive may be influenced by airway resistance.