慢性肝病患者血清TNF-α、IL-8和血浆选择素水平的检测及其意义

摘要

Objective To investigate the relationship between TNF-a, IL-8, P-selectin and chronic hepatic diseases. Methods The serum TNF-α, IL-8 and plasma selectin levels in 124 patients were measured by ELISA. Results The TNF-α, IL-8 and P-selectin levels are significantly higher than normal controls( P＜0.001,P＜0.01). Conclusion The measurements of serum TNF-α, IL-8 and P-selectin levels have clinical value for judgement patients condition and prognosis.%目的 探讨TNF-a、IL-8和P-selectin与慢性肝病的关系。方法 应用双抗体夹心酶联免疫吸附法(ELISA)测定124例慢性肝病患者血清TNF-α、IL-8和P-selectin的水平。结果 慢性肝病患者血清TNF-a、IL-8和P-selectin水平均明显高于对照组(P值均＜0.001，P-selectin组P＜0.01)。结论 TNF-a、IL-8和P-selectin可能参与慢性肝病免疫病理损伤过程。检测血清TNF-α、IL-8和P-selectin水平对判断患者病情和预后有临床实用价值。