代谢综合征合并非酒精性脂肪性肝病患者的临床特点和危险因素

摘要

目的 研究代谢综合征(MS)合并非酒精性脂肪性肝病( NAFLD)患者的临床特点并分析相关危险因素.方法 2009年8月至2010年5月在上海市徐汇区田林街道社区卫生服务中心就诊的MS患者,分为代谢综合征组( MS组)和代谢综合征合并非酒精性脂肪性肝病组(MN组),检测身高、体重、腰围、血压、血液生化.结果MN组合并肥胖、高脂血症的概率高于MS组(P＜0.01),而合并糖尿病则MS组高于MN组(P＜0.05).MN与MS组相比,体重、BMI、腰围、臀围、腰臀比、舒张压、2hPG、TG明显升高(P ＜0.05或P＜0.01).而两组间身高、收缩压、FPG、HDL -C、ALT、VLDL差异无统计学意义.与MS合并NAFLD的相关的危险因素为BMI、TG、腰围.结论MS合并NAFLD时代谢异常程度更明显,BMI、TG、腰围为MS合并NAFLD的危险因素.%Objective To investigate the clinical features and risk factors of metabolic syndrome(MS) combined with non - alcoholic fatty liver disease(NAFLD). Methods Patients of MS who were treated at the Tianlin Community, Xuhui District, Shanghai from August 2009 to May 2010 were prospectively included in the study. The subjects were divided into two groups;simple MS group(MS) and MS combined with NAFLD group(MN). Height,weight, waist circumference,blood pressure, blood biochemistry examinations as well as liver ultrasound were taken. Results The prevalences of obesity and hyperlipemia were higher in MN than that in MS (P <0.01) , while the prevalence of diabetes was lower (P < 0. 05 ). The body weight, BMI, waist circumference, hip circumference, waist to hip ratio, diastolic pressure, 2hBG, TG were significantly increased in MN group as compared with those in MS group (P<0. 05 or P <0.01). But the difference of body height, systolic pressure, FPG, HDL - C, ALT, VLDL did not show statistical significance between the two groups. The relative risk factors of MS combined with NAFLD were BMI ,TG,waist circumference. Conclusion The extent of metabolic abnormality was obvious in patients of MS combined with NAFLD. BMI, TG, waist circumference were strong predictors of MS with NAFLD.