评估肝纤维化进展相关的血清标志物研究现状

摘要

肝纤维化是各种慢性肝病重要的病理特征,也是进一步向肝硬化发展的必经阶段,早期诊断和治疗对阻止肝纤维化发展为肝硬化具有重要意义.肝活检仍是诊断肝纤维化的金标准,但具有创性,不易动态观察,临床应用受到限制,因此需寻求理想的无创诊断方法.在过去的十年中.肝纤维化进展相关的血清标志物研究取得了很大的进展,为肝纤维化的无创诊断带来了新希望.%Liver fibrosis is not only a significant feature of various liver diseases, but also the inevitable stage to liver cirrhosis. In order to prevent the progress to cirrhosis, it is important to diagnose and treat liver fibrosis early. Liver biopsy is still the gold standard for the diagnosis of liver fibrosis. But because its invasive trait and limited repeatability, its application is restricted. Thus it is necessary to seek ideal non - invasive method. Last decade' s breakthroughs of serum markers brought new hope to the diagnosis.