Objective To determine the incidence of osteodystrophy among patients with posthepatic cirrhosis in order to develop effective strategies for prevention and curative treatment of this complex disease. Methods Sixty - five male patients with posthepatic cirrhosis were randomly selected for study. All diagnoses were made by a single hepatopathy professor at our hospital, and patients were excluded from study enrollment based on clinical signs or symptoms of kidney and/or endocrinopathy diseases. Simultaneously, 30 healthy males were selected from among individuals presenting to the hospital for routine physical examinations, and were excluded from enrollment based on presence or suspicion of hepatopathy or kidney and/or endocrinopathy diseases. Venous blood samples were collected from every study participant and used to assess levels of Ca2+ , serum parathyroid hormone, calcitonin, and alkaline phosphatase isozyme (ALP3 ) . Quantitative computed tomography was used to measure the volume of the left radius (at the 1/3 position) and estimate bone mineral density. Results The posthepatic cirrhosis group had significantly lower blood calcium and calcitonin but significantly higher serum parathyroid hormone and bone - derived ALP3 than the healthy group. Conclusion Posthepatic cirrhosis patients in Jilin present with clinical signs of increased bone re-sorption and decreased bone formation. Osteodystrophy was more common among posthepatic cirrhosis patients than healthy controls, indicating that this patient population should be carefully monitored for development of bone degradation conditions to implement timely treatment and preventative measures.%目的 探讨吉林地区肝炎肝硬化患者中骨营养不良的发病情况,为相关并发症的防治提供理论依据.方法 选择肝炎肝硬化的男性住院患者65例作为研究对象组,所选人群均排除肾脏疾病及内分泌系疾病.选择普通男性健康人群30例为对照组,所选人群均排除肝病、肾脏疾病及内分泌系疾病.检测Ca2+、血清甲状旁腺素(PTH)及降钙素(CT)、碱性磷酸酶同工酶(ALP3)、左侧桡骨下1/3处骨密度值.结果 研究对象组存在明显的血钙水平偏低,并且伴有PTH升高而CT水平相对偏低,骨源性ALP3明显高于对照组,骨密度降低.结论 吉林地区肝硬化患者普遍存在骨吸收增加、骨形成下降的情况,主要表现为骨营养不良及骨质疏松症.
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