环氧合酶-2与非酒精性脂肪性肝炎关系的研究进展

摘要

非酒精性脂肪性肝炎( NASH)呈慢性肝脏脂毒性炎症表现,是非酒精性脂肪性肝病(NAFLD)的重要转折点,存在肝病重症化趋势.环氧合酶-2(COX -2)作为启动炎症反应的关键酶同样涉及到NASH的形成及进展.本文就COX -2及其抑制剂与NASH关系的研究予以综述.%Nonalcoholic steatohepatitis (NASH) is characterized by chronic states of fatty liver infiltration and lipotoxic inflammation. NASH is considered a critical process for the progression of non - alcoholic fatty liver disease ( NAFLD) to the severe stage. Cyclooxygenase -2 ( COX -2) , a key pro - inflammatory factor, has been implicated in NASH pathogenesis. In this review, we discuss the recent findings concerning both the role of COX - 2 in NASH and the potential therapeutic promise of COX - 2 inhibitors.