磷脂酰肌醇蛋白多糖-3介导的信号通路与肝癌靶向治疗

摘要

Glypican-3 ( GPC-3) signaling pathways contribute to the development and progression of hepatocellular carcinoma ( HCC). As a specific diagnostic marker of HCC, GPC-3 may also represent a novel therapeutic target. Recent studies have shown that molecular targeting of GPC -3 can significantly inhibit growth of HCC cells, as well as enhance apoptosis. Here, we discuss the underlying mechanisms of the GPC-3-mediated anti-proliferative and pro-apoptotic effects in HCC, which may help in development of improved GPC-3 targeted therapy.%磷脂酰肌醇蛋白多糖(GPC)-3相关信号通路与肝细胞癌(HCC)发生发展密切相关.GPC-3除用于HCC特异诊断外,靶向GPC-3可明显抑制HCC细胞增殖并诱导凋亡,有望成为HCC的分子靶目标.