胰性脑病脱髓鞘病变与髓鞘碱性蛋白的相关性

摘要

Pancreatic encephalopathy (PE)is one of the severe complications of severe acute pancreatitis (SAP).Early diagnosis mostly depends on the history of disease as well as clinical symptoms and signs.PE progresses rapidly and is often complicated by multiple organ dysfunction,and it may finally develop into multiple organ failure with a high fatality rate if not treated in time.It is currently known that de-myelination is one of the important pathological features of this disease,with fat -soluble demyelination of cerebral gray matter and white matter,as well as inflammatory changes such as hemorrhage and edema.The target antigen of demyelinating lesions,however,is myelin basic protein (MBP).This paper reviews the changes in MBP levels in the demyelinating lesions of the central nervous system among PE pa-tients,with the purpose of providing clues for the early diagnosis and prognostic study of demyelinating lesions in PE.%胰性脑病（PE）是重症急性胰腺炎（SAP）的严重并发症之一，早期诊断多依靠病史、临床症状及体征，病情发展快，合并多脏器功能不全，治疗不及时可发展多脏器功能衰竭，病死率高。现已知脱髓鞘是该病的重要病理特征，表现是脑灰质、白质的脂溶性脱髓鞘及出血、水肿等炎症改变。然而脱髓鞘病变的靶抗原是髓鞘碱性蛋白（MBP）。综述了 PE 中枢神经系统发生脱髓鞘病变时 MBP 水平变化，旨在为 PE 脱髓鞘病变、早期诊断及预后研究提供线索。