直接抗病毒药物时代精准临床检测在丙型肝炎患者全程管理中的作用

摘要

Hepatitis C virus (HCV) infection is an important public health issue around the world.Direct-acting antiviral agents (DAAs) have become an important method to reduce HCV infection.DAAs can improve the clinical outcome of antiviral therapy,shorten the course of treatment,and reduce complications and have a wide range of application;therefore,they have great advantages over conventional therapies.Accurate clinical diagnosis has increasing importance in the era of DAAs and guarantees the whole management process of chronic hepatitis C patients from the aspects of disease diagnosis,therapeutic regimens,outcome evaluation,and long-term prognosis monitoring.%HCV感染是全球重要的公共卫生问题.直接抗病毒药物(DAA)已成为减少HCV感染的重要手段.此类药物能提高抗病毒治疗的疗效、缩短疗程、减少并发症出现,并且适用范围更广,具有以往治疗方法不可比拟的优势.在DAA治疗的背景下,精准临床诊断的作用及意义变得尤为重要,为慢性丙型肝炎患者在疾病诊断、治疗方案的确定、疗效评价以及停药后长期预后监测等方面提供了全程保障.