我院2010年铜绿假单胞菌的临床分布及耐药情况分析

摘要

Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa ( P. Aeruginosa ) in our hospital in order to offer reference to control nosocomial infection and guide drug treatment in clinic. Methods The strains and drug resistance of P. Aeruginosa were detected by Walkaway automatic bacterium identifying and drug sensitivity analyzing systems, and the drug resistance was analyzed. Results P. Aeruginosa were mainly isolated from patients in Department of Thoracic Surgery( 34. 83% ) and Department of Neurosurgery ( 20. 22% ). Among the 178 specimens, the dominant specimen was sputum ( 49. 44% ). The drug resistant rates to most antibacterials were high, and showed low drug resistant rate to piperacillin/tazobactam, cefoperazone/sulbactam and imipenem. Conclusion P. Aeruginosa is multi - drug resistant. Rational application of antibiotics and standard prevention should be strengthened to control the nosocomial infection caused by P. Aeruginosa.%目的 分析铜绿假单胞菌的耐药情况,为医院合理使用抗菌药和控制医院感染提供可靠的实验依据.方法 收集医院2010年1月至2010年12月各临床科室送检的标本并对其进行细菌分离、培养、鉴定及药敏试验.结果 铜绿假单胞菌主要分布在心胸肿瘤外科(34.83%)、神经外科(20.22%);分离标本来源主要为痰(49.44% );菌株对多种抗生素有较高的耐药性,对哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、亚胺培南敏感性较高.结论 铜绿假单胞菌呈现多重耐药性,应合理使用抗生素和加强医院感染监控,减少其引发的严重感染的发生.