盐酸氟西汀配合中成药治疗孕中期引产产妇产后抑郁的研究

摘要

目的 探讨盐酸氟西汀联合中成药治疗中孕引产产妇产后抑郁的临床疗效和不良反应.方法 将46例孕中期引产产妇产后抑郁患者随机分为研究组(氟西汀20 mg/d配合中成药组)和对照组(单用氟西汀20 mg/d组),每组各23例,共治疗6周.用汉密尔顿抑郁量表(HAMD)评定疗效,用药物不良反应量表(TESS)评定不良反应.结果 治疗6周后,研究组与对照组总有效率分别为95.6%和95.6%,两组比较差异无显著性.研究组起效快,与对照组比较,在治疗的第1周末及出现显著差异(P0.05).结论 盐酸氟西汀联合中成药治疗孕中期引产产妇产后抑郁比单用盐酸氟西汀起效快,药物副作用小.%Objective To investigate the curative effect and adverse reaction of fluoxetine hydrochloride in combination with Chinese traditional patent medicine in the treatment of postpartum depression after induction of labour in second trimester. Methods Forty - six patients with postpartum depression after induction of labour in second trimester were randomly divided into fluoxetine - Chinese traditional patent medicine treatment group ( 23 patients ) and fluoxetine treatment group ( 23 patients ), Patients in both groups were treated for 6 wks. The efficacy and the adverse effect of the treatment were evaluated with Hamilton depression rating scale ( HAMD ) and adverse drug reactions scale ( TESS ) respectively. Results after 6 wks treatment, the total effective rate in both groups was 95. 6%. Compared with fluoxetine treatment group, rapid effect was observed in fluoxetine - Chinese traditional patent medicine treatment group at wk 1 ( P 0. 05 ). Conclusion Fluoxetine hydrochloride combined with Chinese traditional patent medicine effects quickly and presents less adverse effect for the treatment of postpartum depression after induction of labour in second trimester.