胃癌患者血清胸苷磷酸化酶表达与临床病理特征、化疗疗效及预后关系的研究

摘要

Objective To explore the relationship among serum levels of thymidine phosphorylase ( TP ) and efficacy of fluouracil - based chemotherapy in treatment of patients with advanced gastric cancer. Methods Serum samples from 88 patients before chemotherapy during January 2010 to June 2012 in this hospital were collected. Serum level of TP was analyzed by using EL1SA. Results The expression of TP in patients with peritoneal metastasis was significantly lower than that in patients without peritoneal metastasis ( P =0.017). There was no difference between serum level of TP and clinical beneficial rate ( CBR ). The median progression - free survival ( PFS ) and overall survival ( OS ) in patients with high level of TP were longer than those of patients with low level of TP ( PFS:177 d vs. 106 d, P=0. 067 ;OS :417d vs. 222d, P=0.002 ). Conclusion In patients with advanced gastric cancer received first - line fluorouracil - based chemotherapy, patients with high level of TP will get better prognosis than those with low level of TP.%目的 探讨晚期胃癌患者血清胸苷磷酸化酶(TP)水平与临床病理特征及以氟尿嘧啶为基础的化疗疗效和预后的关系.方法 选取2010年1月至2012年6月于北京友谊医院消化内科接受治疗的晚期胃癌患者化疗前血清,用酶联免疫吸附试验(ELISA)方法检测血清中TP表达水平.结果 血清TP表达水平与性别、年龄、组织分化程度、KPS评分、肝转移及淋巴结转移无明显相关,腹膜转移患者的TP表达水平显著低于无腹膜转移患者(P=0.017),TP高表达患者与低表达患者的临床获益率无显著差异,但TP高表达患者的无进展生存期(PFS)和总生存期(OS)均长于低表达患者(PFS:177 d vs.106 d,P=0.067;OS:417 d vs.222 d,P=0.002).结论 在接受氟尿嘧啶为基础的化疗的胃癌晚期患者中,血清TP高表达的患者预后较低表达患者好.