Objective To investigate the influence of intrahepatic cholestasis of pregnancy( ICP)combined with HBV infection on preg-nant women and perinatal infants. Methods Eighty-two ICP pregnant women combined with HBV infection were chosen as the observation group,55 pregnant women with simple ICP were as control. Perinatal complications,perinatal infants status and ALT,TBIL,CG,AST,DBIL and other liver function parameters at 1 week prenatal and postpartum were compared. Results The rates of pregnancy-induced hypertension (24. 4%),cesarean section(92. 7%),premature birth rate(68. 3%)and the probability of postpartum hemorrhage(28%)in observation group were significantly higher than those in control group(all P 0. 05). Prenatal maternal ALT,TBIL,TBA,AST and DBIL in the observation group were signifi-cantly higher than those in control group(all P 0.05）。②观察组产妇产前ALT、TBIL、TBA、AST以及DBIL等肝功能相关指标均显著高于对照组（ P <0.05）。产后1周，两组肝功能相关指标均显著降低，与产前比较，差异具有统计学意义（ P <0.05）。两组间比较，观察组各项肝功能相关指标均显著高于对照组（ P <0.05）。结论 ICP合并HBV感染孕妇围产期并发症发生率高，肝功能损伤重，除实施有效措施阻滞HBV母婴传播外，同时还应密切监测孕妇病情，采取积极的预防和治疗措施。
展开▼
