高血压心血管危险分层与左室舒张功能障碍及 NT - proBNP 的相关性研究

摘要

目的：分析左室舒张功能障碍及 N 端脑肽钠前体（NT - proBNP）等相关指标与高血压患者心血管危险分层的相关性。方法根据我国高血压防治指南对于高血压心血管危险分层的标准，将2012年1月至2014年1月接受治疗154例高血压患者分为极高危组（34例）、高危组（36例）、中危组（40例）以及低危组（44例），另选取同期进行体检的健康志愿者40例作为对照组，分析各个组之间左室舒张功能及 NT - proBNP 等指标的变化及相关性。结果由于本研究各项指标均不满足正态分布的规律，故采用 Spearman 秩相关分析检验各个指标之间的相关性，结果发现除了 E波衰减时间（DCT）与左室等容舒张时间（IVRT）、左室重量指数（LVMI）与 IVRT 无明显的线性关系外，其他各项指标之间均呈现线性关系。采用 Mann - Whitney 非参数检验，结果发现除了 DCT 与 IVRT 两组之间无显著差异外，其他各项指标均有显著性差异，其中 LVMI 以及 NT - proBNP 高血压组均显著大于对照组。采用 Mann - Whitney 非参数检验，结果发现除了 DCT 与 IVRT 两组之间无显著差异外，其他各项指标均有显著性差异，其中 LVMI 以及 NT - proBNP 高血压组均显著大于对照组。经 Spearman 秩相关分析发现，除了 DCT 与组别危险程度无相关性外，其他各指标与组别程度均具有明显的相关性。结论高血压患者随着心血管危险分层的逐渐提高，NT - proBNP 水平也之间升高。检测 NT - proB-NP 水平有助于对高血压患者进行心血管危险分层。%Objective To explore the correlation between left ventricular diastolic dysfunction and NT - proBNP and other related indexes and cardiovascular risk stratification in patients with hypertension. Methnds From January 2012 ~ 2014 in January,we treated 154 patients with hypertension. According to the guidelines of hypertension prevention and control for hypertension and cardiovascular risk stratification standard, patients were divided into high risk group(34 cases),high risk group(36 cases)and intermediate risk group(40 cases)and low risk group(44 cases). At the same time,we selected another 40 cases from the hospital for examination of normal volunteers as the control group. The analysis of the changes and correlation of the correlation index between the various groups were performed. Results The indexes in this study did not satis-fy the law of normal distribution,therefore the Spearman rank correlation analysis was performed between each index of correlation. The results showed that LVMI and IVRT did not have obvious linear relationship in addition to the DCT and IVRT. Other indicators showed a linear relation-ship by the Mann Whitney nonparametric test. The results showed that no significant difference was found in addition to the DCT and IVRT be-tween the two groups. The other indicators were significantly different. LVMI and NT proBNP in hypertension group were significantly higher than that of the control group using the Mann Whitney nonparametric test. The results showed that no significant difference was found between the two groups in addition to the DCT and IVRT. The other indicators were significantly different. LVMI and NT proBNP in hypertension group were signif-icantly higher than that of the control group. The Spearman rank correlation analysis found that the DCT and group risk degree had no correlation, other indexes and group level has obvious correlation. Cniclusini Hypertensive patients with a gradual increase in cardiovascular risk stratifica-tion,NT proBNP levels were also elevated in hypertensive patients of cardiovascular risk stratification. This index has important significance in dis-ease control,it is worth in clinical promotion.