Objective To study the impact of early intensive antihypertensive treatment to expression of high mobility rate protein -1 and C- reactive protein in patients with acute cerebral hemorrhage. Methods 100 patients with acute cerebral hemorrhage in our hospital from Janu-ary 2012 to January 2014 were studied,and they were divided into the control group( January 2012 to January 2013 )and the observation group ( February 2013 to January 2014)according to the order of their admission,50 cases each. The control group received conventional treatment,and the observation group received early intensive antihypertensive treatment on the basis of the control group. To analyze serum high mobility protein-1(HMGB-1)and C- reactive protein(CRP)levels,the degree of neurological deficit score(NDS)before and after treatment of the two groups of patients,and assess the total treatment efficiency of the two groups. Results Serum HMGB-1 levels,CRP levels and NDS score of the two groups did not have significant difference before treatment,without statistically significant( P >0. 05). The three indicators in two groups of patients after treatment declined. And the decrease of the observation group is more obvious. The comparison of two groups was statistically signifi-cant( P 0.05）；在治疗后两组患者的这三项指标均有所下降，且观察组下降的幅度更为明显，差异具有统计学意义（ P <0.05）。对照组治疗总有效率为66.00%，而观察组为90.00%，观察组的治疗总有效率明显高于对照组，差异具有统计学意义（ P <0.05）。结论早期强化降压治疗可以有效降低急性脑出血患者血清HMGB-1水平及CRP水平，治疗急性脑出血的临床效果良好。
展开▼
