甲状腺疾病诊治中血清TpoAb、TGAb的变化及其价值

摘要

目的：探讨抗甲状腺过氧化物酶抗体（TpoAb）和抗甲状腺球蛋白抗体（TgAb）在甲状腺疾病诊断中的临床价值。方法选取2011年10月至2015年9月甲状腺疾病患者357例，同期体检健康者50例（正常对照组），根据疾病诊断将患者分为两组（A 组和 B 组），A 组为非自身免疫性甲状腺疾病（单纯性甲状腺肿、甲状腺肿瘤、甲状腺功能亢进、原发性甲状腺功能减退症），B 组为自身免疫性甲状腺疾病（Graves 病，桥本病），对比观察两组以及两组与正常对照组 TgAb 和 TpoAb 含量的差异。然后将各疾病作为亚组，对比各疾病间 TgAb 和 TpoAb 测定结果间的差异。结果 B 组两种抗体阳性率、测定结果均显著高于 A 组；单纯性甲状腺肿、甲状腺腺瘤血清 TgAb 和 TpoAb 测定结果与正常对照组比较，差异无统计学意义（ P >0.05）；分化型甲状腺癌、甲状腺功能亢进、原发性甲状腺功能减退症、Graves 病、桥本病患者的 TgAb 水平及 TpoAb 水平均高于正常对照组（ P 0. 05). TgAb,TpoAb levels of differentiated thyroid cancer,hyperthyroidism,primary hypothyroidism,Graves′disease,hashimoto′s disease were higher than those in normal control group( P <0. 05). The TpoAb level in Hashimoto′s disease and TgAb level in Graves′disease were significantly higher than other groups,respectively( P < 0. 05). TgAb and TpoAb positive rate in patients with differentiated thyroid cancer were higher than those of the thyroid adenoma( P < 0. 05). Conclu-sion Serum TgAb,TpoAb is of important clinical value in the diagnosis of thyroid diseases.