Objective To explore the clinical efficiency of retinal laser photocoagulation with one time multi - point scanning mode and multiple time single - point mode in treatment with non proliferative diabetic retinopathy patients. Methods A total of 86 cases(102 eyes)of non proliferative diabetic retinopathy patients treated in hospital from June 2011 to June 2014 were randomly divided into study group of 43 cases(53 eyes)and the control group of 43 cases(49 eyes),study group underwent one time multi - point scanning mode,control group was given multiple time single - point mode,the laser energy,spot number,laser energy density of the two groups were compared,and detected visual threshold sen-sitivity,flash electroretinogram a,b wave and central macular thickness between two groups before and after 1 month,3 month,6 month treatment. Results The laser energy in the study group was significantly higher than that in the control group,the spot number,laser energy density was sig-nificantly lower than that in the control group( P 0. 05). There was no significant difference between the two groups before and after treatment in CMT( P > 0. 05). After treatment,visual threshold sensitivity,F - ERG a,b wave first showed reduce trend,and then gradually rised,after 1 month,3 month treatment visual threshold sensitivity,F - ERG a,b wave were significantly lower than before treatment( P 0. 05). There were no obvious perfusion area and neonatal blood vessels and other serious adverse reactions occurred during the 6 month follow - up period in two groups. Con-clusion The visual improvement effect of one time multi - point scanning mode and multiple time single - point mode in treatment with non prolif-erative diabetic retinopathy patients are similar,and one time multi - point scanning mode can significantly reduce the energy density,maximum reduction of laser treatment amage caused by the retina.%目的探讨单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效。方法将2011年6月至2014年6月医院收治的86例（102只眼）非增生期 DR 患者按照随机数字表法分为研究组43例（53只眼）和对照组43例（49只眼），研究组采用多点扫描模式一次性完成视网膜激光光凝，对照组采用单点扫描模式分3~5次完成视网膜激光光凝；比较两组患者激光能量、光斑数、激光能量密度，分别于治疗前、治疗后1、3、6个月检测两组患者视野阈值敏感度、全视野闪光视网膜电图 a、b 波振幅及黄斑中心凹厚度。结果研究组激光能量显著高于对照组，光斑数、激光能量密度显著低于对照组，两组间比较差异具有统计学意义（ P ＜0.05）；研究组和对照组最佳矫正视（BCVA）显著提高（ P ＜0.05），两组间 BCVA 比较差异无统计学意义（ P ＞0.05）；两组治疗前后及组间黄斑中心凹厚度（CMT）比较差异均无统计学意义（ P ＞0.05）。治疗后两组患者全视野闪光视网膜电图（F - ERG）a、b 波振幅、视野阈值敏感度先呈降低趋势，然后逐渐上升，其中治疗1个月、3个月两组患者 F - ERG a、b 波振幅、视野阈值敏感均显著低于治疗前组（ P ＜0.05）；两组间治疗前后各时段 F - ERG a、b 波振幅、视野阈值敏感比较差异均无统计学意义（ P＞0.05）。两组患者治疗后6个月随访期间均未出现明显灌注区及新生血管等严重不良反应。结论单点多次和多点一次性完成视网膜激光光凝治疗非增生期 DR 对患者视力改善情况相当，而多点一次完成视网膜激光光凝能够显著降低能量密度，最大程度降低因激光治疗对视网膜造成的损伤。
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