SNCG、BMP-2、MMP-9在口腔颌面部鳞癌中的表达情况及相关性

摘要

目的 探讨神经突触核蛋白-γ(SNCG)、骨形态发生蛋白2(BMP-2)、基质金属蛋白酶9(MMP-9)在口腔颌面部鳞癌中的表达情况及相关性.方法 选取2010年1月至2015年12月存档的口腔颌面部鳞癌组织蜡块标本67 例,以及相应的癌旁组织67例和41例正常组织作为对照组.采用免疫组化EnVision二步法检测SNCG、BMP-2、MMP-9在三组的表达,并分析SNCG、BMP-2、MMP-9三者之间的相关性.结果 SNCG和MMP-9在肿瘤组织中阳性率显著高于在正常组织和癌旁组织(P0.05);BMP-2在肿瘤组织和癌旁组织中的阳性率显著高于正常组织(P0.05).BMP-2、MMP-9中在病理分级中的阳性率比较差异无统计学意义(P>0.05),SNCG在高分化组的阳性表达率显著低于在中、低分化组(P0.05).除BMP-2外,SNCG、MMP-9均在已发生淋巴结转移的组织中的阳性表达率显著高于在未发生淋巴结转移的组织(P0.05).The incidence rates of BMP-2 in tumor tissue and adjacent tissue were significantly higher than that in normal tissue (P0.05) in tumor tissue and tissue adjacent.The positive rates of BMP-2, MMP-9 had no statistical significance (P>0.05) in pathological grading;the positive expression rate of SNCG in high differentiation group was significantly lower than in the middle and low differentiation groups (P0.05).Except for BMP-2, the expression of SNCG and MMP-9 in metastatic tumor were higher than that in non-metastatic tumor, and there was significant difference (P<0.05).The expression of SNCG, BMP-2 and MMP-9 were positively correlated (P<0.05).Conclusion The excessive expression of SNCG, BMP-2 and MMP-9 in oral and maxillofacial carcinoma is positively associated with the differentiation degree of carcinoma.So the expression of SNCG, BMP-2 and MMP-9 are expected to be the marker in the tumor of oral and maxillofacial carcinoma for the judgment.