Objective In order to compare the analgesic effects of tramadol and tramadol combined with ramosetron used in laparoscopic myomectomy.Methods Eighty patients undergoing gynecologic laparoscopic myomectomy were randomly allocated to one of two groups: T (tramadol) group (n=40) and TR (tramadol conbined with ramosetron) group (n=40).All patients received general anesthesia inhalation, and patients in group T received tramadol 2 mg/kg, while the patients in group TR received tramadol 2 mg/kg and Ramosetron 0.3 mg.Pain score(VAS) and the incidence of nausea and vomiting were recorded at the time of tracheal extubation.Results There were no significant difference in pain scores between group T and group TR at each point (P>0.05).The number of nausea in both groups was 30 cases and 20 cases, respectively, Vomiting 18 cases and 8 cases.The incidence of nausea and vomiting of group T was significantly lower than that of group TR (P0.05).两组的恶心发生例数分别为30例,20例,呕吐的发生例数为18例,8例.TR组的恶心、呕吐发生率明显低于T组(P<0.05).结论 腹腔镜子宫肌瘤剔除术围术期使用雷莫司琼与曲马多联合应用与单独使用曲马多比较镇痛效果没有显著差异,雷莫司琼可降低曲马多引起的术后恶心呕吐的发生率.
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