丹参粉针注射用药对溃疡性结肠炎受试者D-二聚体、PT、FIB、PLT的影响

摘要

目的 探讨丹参粉针注射用药对溃疡性结肠炎受试者的治疗效果及对其炎性因子与凝血指标的影响.方法 前瞻性选取2015年10月至2017年10月接收的120例溃疡性结肠炎受试者.将其随机分两组,对照组60例予以美沙拉嗪肠溶片治疗,观察组60例在对照组基础上加用丹参粉针注射治疗,均治疗18d.均在入院时及治疗18d时检测患者D 一 二聚体(D-D)、凝血酶原时间(PT)、纤维蛋白原(FIB)、血小板计数(PLT)等凝血指标及IL-6、IL-8以及TNF-α等炎性因子,并于治疗18d时观察疗效.结果 治疗18d后组间临床疗效差异有统计学意义(P＜0.001),观察组(91.3％)受试者临床的有效率高于对照组(78.3％)(P＜0.05),复发率也低于对照组(P＜0.05).治疗前两组受试者的IL-6、IL-8以及TNF等三种炎性因子水平组间均无显著差异(P＞0.05).治疗18d后,两组上述指标水平均显著较治疗前下降,且治疗18d后观察组IL-6、IL-8、TNF-α水平低于对照组,组间差异显著(P＜0.05).组间治疗前凝血指标水平差异无统计学意义(P＞0.05).治疗18d后两组FIB、PLT、D-D水平均显著降低,PT明显较治疗前缩短,且观察组FIB、PLT、D-D水平均明显较对照组低,PT显著较对照组长(P＜0.05).在治疗期间,两组受试者中均有不同程度的不良反应,但程度都很轻.结论 美沙拉嗪联合丹参粉注射药能减轻炎性反应,降低受试者血液的高凝状态,提高临床治疗的效果,且不良反应较轻,值得在临床上推广应用.%Objective To investigate the effect of salvia miltiorrhiza injection on D-dimer, PT, FIB and PLT in patients with ulcerative colitis and the effects on inflammatory factors and coagulation parameters. Methods 120patients with ulcerative colitis admitted to our hospital from October 2015to October 2017 were selected. They were randomly divided into two groups, the control group of 60patients treated with mesalazine enteric-coated tablets,the observation group of 60patients based on the control group combined with the use of Salvia powder injection, treated for 30days. The indexes of blood coagulation, such as D-dimer, PT, FIB and PLT,IL-6, IL-8and TNF-a were detected at admission and 30days after treatment. Results After 30days of treatment, there was significant difference in clinical efficacy between the two groups(P＜0.001). The clinical effective rate of the observation group (91.3％) was higher than that of the control group (78.3％) (P＜0.05), and the recurrence rate was also lower than that of the control group (P＜0.05). The levels of IL-6,IL-8and TNF-a in the two groups before treatment had no significant difference (P＞0.05). After 30days of treatment, the levels of these indexes in both groups were significantly lower than those before treatment, and the levels of IL-6,IL-8and TNF-a in the observation group were lower than those in the control group after 30days of treatment, showing significant difference (P＜0.05). There was no significant difference in coagulation index between the two groups before treatment (P＞0.05). After 30days of treatment, the levels of FIB,PLT and D-D in both groups were significantly decreased. PT was significantly shorter than before treatment. The levels of FIB,PLT and D-D in the observation group were significantly lower than those in the control group (P＜0.05). During treatment, both groups of patients had varying degrees of adverse reactions, but to a lesser extent. Conclusion Mesalazine combined with salvia miltiorrhiza injection can reduce inflammatory reaction and reduce the hypercoagulability of blood. Improve the effect of clinical treatment, and the adverse reaction is mild,so we can do further application in clinic.