利多卡因预防丙泊酚注射痛最短预处理时间的临床观察

摘要

Objective To explore the shortest time of lidocaine pretreatment on propofol injecting paia Methods One hundred and fifty adult patients undergoing abortion were divided into experimental group (group To ,T10, T30 .T45) and control group (group D) with 30 each. Veins were occluded 10 cm before the puncture point and 1% lidocaine 4 ml were injected 0,15.30.45 seconds prior to propofol injection at the rate of 0. 5 ml/s . Injecting pain was evaluated in all groups. Results The incidences of painlessness were higher and moderate injecting pain, recalling pain and VAS scores were lower in group T15, T30 , T45 than group D and group To (P<0. 05). Severe injecting pain in group To, T15, T30. T45.was significantly lower than that in group D(P<0.05). There was no significant difference among group T15, T30 and T45. Conclusion Lidocaine pretreatment 15-30s prior to injection can effectively prevent propofol injecting pain. However, this protective effect can not be increased with more pretreatment duration.%目的 探讨利多卡因预防丙泊酚注射痛最短预处理时间.方法 符合条件的150例实施无痛人流的患者,随机分为研究组(T0、T15、T30、T40组)和对照组(D组),每组30例,先在穿刺点近心端10 cm用压脉带阻断静脉,抽取1％利多卡因4 ml或生理盐水注入手背静脉,研究组等待一定时间(分别为0、15、30、45 s)再按0.5 ml/s的速度推注丙泊酚,观察五组注射痛情况.结果 与D组和T0组比较,T15、T30、T45组无痛率明显升高；中度、注射痛、回忆痛和VAS评分明显降低(P＜0.05):T0、T15、T30、T45组重度痛明显低于D组(P＜0.05).T15、T30、T45组间差异均无统计学意义.结论 压脉带阻断静脉推注利多卡因预处理15～30 s即可有效预防丙泊酚注射痛,随着阻断延长,预防效果不再提高.